The Immunologic Constant of Rejection (ICR), is a set of genes that is involved in tissue destruction along a diverse set of physiological circumstances like autoimmune disease or allograft rejection or pathological conditions like infection and cancer.
Important geneset within the ICR consist of:
In several cancers these genes show great correlation, a high expression of these genese indicates an active immune engagement and, at least a partial rejection of the cancer tissue. This phenotype is associated with a better prognosis and thus longer survival time. In breast cancer the increased survival time observed in patiens displaying a high level of ICR gene expression was found to be associated with increased level of mutation of the tumor tissue while the poor immune pheneotype was defined by perturbation in the MAPK signalling pathways.